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Overview of Infertility
Definition: 1 year of well-timed uprotected intercourse without a pregnancy without a pregnancy without a pregnancy

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Causes of Infertility
Infertility is the inability to conceive a child. A couple may be considered infertile if, after two years of regular sexual inter-course,

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What is a Ivf
Exceptional pregnancy rates with less than 5% incidence of triplets and 1 quadruplet pregnancy in the past 5 years.

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Welcome to History of Infertility

First Written document dealing with infertility may be found in the kahoun papyrus (oldest Egyptian medical text), dated to 2200 - 1950 BC the early attribution of infertility to women persisted for countries and was often considered divine punishment the only solution to infertility was prayer - to Egyptian Isis, Phoenician Astarte, Greek Aphrodite, or Roman Venus. He role of the human male in reproduction was not understood in past civilizations and is still veiled in mystery for many of the primitive tribes

Ovary - Female Age

Women are born with their lifetime

egg supply

4 million at 20 weeks gestation

400,000 at birth

100,000 eggs left at time of puberty

Fertility initially declines at age 27

Cause of Female Infertility








How many are needed for fertilization?

Natural Conception


Intra-uterine insemination


In-vitro fertilization (IVF)


Egg Donation(Exceptional Donors)

Egg Donation(Exceptional Donors)
October 23, 1999
Selling Fashion Models' Eggs Online Raises Ethics Issues
By Carey Goldberg
CAMBRIDGE, Mass. To the horror and disgust of mainstream infertility groups, a longtime fashion photographer has begun offering up models as egg donors to the highest bidders, auctioning their ova via the internet to would be parents willing to pay up to $150,000 in hopes of having a beautiful child.

Initial Screening-Egg and Sperm Donors

Medical History (especially past history of donation in the case of egg donors so protocol and out-come can be reviewed)
Physical and Clinical Assessment
Genetic Testing (as repquired based on Ethnic background and Family and Medical History) Serologic (lab) Testing, STD tests, Drug Screening
Sexual partners of donors are screened for infectious diseases when donors are being evaluated for eligibility
Screening results for donors are good for 6 moths only

Preimplantation Genetic Diagnosis (PGD)

Can test embryos for genetic abnormalities prioor to implantation

Has been successfully used in diagnosing and preventing inherited genetic diseases like Cystic Fibrosis, Tay Sach's Thalassemia, Sickle cell
Anemia and may be potentially used to screen for cancer mutations. Uses single cell (blastomere) at 8-cell stage